Structure of PDB 8f22 Chain B

Receptor sequence
>8f22B (length=200) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)) [Search protein sequence]
PIVQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQDLNTM
LNTVGGHQAAMQMLKETINEEAAEWDRLHPAPGREPRGSDIAGTTSTLQE
QIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRD
YVDRFYKTLRAEQASATETLLVQNANPDCKTILKALGPGATLEEMMTACQ
3D structure
PDB8f22 Structure of a benzosulfonamide based inhibitor - bound to a disulfide stabilised HIV-1 capsid hexamer
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XBQ B N53 L56 N57 M66 K70 T107 Y130 N48 L51 N52 M61 K65 T94 Y117
BS02 XBQ B Y169 R173 Q176 T186 Y156 R160 Q163 T167
Gene Ontology

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Biological Process
External links
PDB RCSB:8f22, PDBe:8f22, PDBj:8f22
PDBsum8f22
PubMed
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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