Structure of PDB 8eym Chain B

Receptor sequence
>8eymB (length=331) Species: 318161 (Shewanella denitrificans OS217) [Search protein sequence]
TTNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGS
SDHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGR
SPDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAAT
KSYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLT
DVKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEK
KLSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLAL
LQRFYIDVAAVAIALGINPDKPAGLKKVTQT
3D structure
PDB8eym Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases.
ChainB
Resolution2.311 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 16G B Y62 R212 S238 E241 Y60 R210 S236 E239
BS02 16G B R50 D54 A74 A75 P77 S78 R48 D52 A72 A73 P75 S76
BS03 AGP B R50 S52 S98 Q99 S100 A150 A151 K225 E228 R48 S50 S96 Q97 S98 A148 A149 K223 E226
Gene Ontology
Molecular Function
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0008483 transaminase activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:8eym, PDBe:8eym, PDBj:8eym
PDBsum8eym
PubMed37145875
UniProtQ12KP2

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