Structure of PDB 8eyb Chain B

Receptor sequence
>8eybB (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSP
FDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWE
QKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKS
YYTVRQLELENLTTQETREILHFHYTTWPAFGVPESPASFLNFLFKVRES
GSLSPEHGPVVVHASAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLL
EMRKFRMGLIATADQLRFSYLAVIEGAKFIMAAAQDQWKELSHE
3D structure
PDB8eyb Structure guided studies of the interaction between PTP1B and JAK.
ChainB
Resolution2.349 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N44 R45 Y46 R47 D48 F182 A215 S216 A217 G218 I219 G220 R221 N43 R44 Y45 R46 D47 F181 A214 S215 A216 G217 I218 G219 R220
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8eyb, PDBe:8eyb, PDBj:8eyb
PDBsum8eyb
PubMed37316570
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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