Structure of PDB 8ewy Chain B

Receptor sequence
>8ewyB (length=1049) Species: 10090 (Mus musculus) [Search protein sequence]
PEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALY
DESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSP
KEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMA
VLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNV
FKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLI
SSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNEEWNNFSYFPEITH
IVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAHHYLC
TDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDN
ILMTVTKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNI
SFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQG
EHLGRGTRTHIYSGTLLDYEKKIKVILKVLDPSHRDISLAFFEAASMMRQ
VSHKHIVYLYGVCFRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKV
AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPV
SVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPL
KDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRD
INKLEEQNPDIVTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQV
AVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLI
MEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLA
ARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQ
CKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK
3D structure
PDB8ewy Structural basis of Janus kinase trans-activation.
ChainB
Resolution5.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B L880 G881 A905 E956 F957 L958 D1020 L776 G777 A801 E852 F853 L854 D916
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:8ewy, PDBe:8ewy, PDBj:8ewy
PDBsum8ewy
PubMed36867534
UniProtP52332|JAK1_MOUSE Tyrosine-protein kinase JAK1 (Gene Name=Jak1)

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