Structure of PDB 8eqz Chain B

Receptor sequence
>8eqzB (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVEAAKWSQVRKDLCS
LKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFA
KVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCL
EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQ
HRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHT
QRLLRIQDIHPFATPLMQELFGISLTERHKILHRLLQEGS
3D structure
PDB8eqz Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
ChainB
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WQB B L209 M243 Q285 F288 W299 Y306 M323 H407 L51 M85 Q127 F130 W141 Y148 M165 H249
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8eqz, PDBe:8eqz, PDBj:8eqz
PDBsum8eqz
PubMed36848571
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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