Structure of PDB 8epk Chain B

Receptor sequence
>8epkB (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDAGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
3D structure
PDB8epk An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa.
ChainB
Resolution2.65 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B K126 K132 L162 V163 D164 R165 L169 Y177 N178 R233 N236 K113 K121 L150 V151 D152 R153 L157 Y165 N166 R223 N226
BS02 rna B F145 K148 F134 K136
BS03 CA B E70 N72 I73 E75 E77 E80 E55 N57 I58 E60 E62 E65
External links
PDB RCSB:8epk, PDBe:8epk, PDBj:8epk
PDBsum8epk
PubMed38985762
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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