Structure of PDB 8emt Chain B

Receptor sequence
>8emtB (length=1221) Species: 9606 (Homo sapiens) [Search protein sequence]
ELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVM
ISRYNPITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQER
IAKCHGTQCGFCTPGMVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYR
PIIDACKTFCKELIFPPELMIMAEKQSQRTRVFGSERMMWFSPVTLKELL
EFKFKYPQAPVIMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHAYNG
LTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMA
SLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNA
DLKPQEILVSVNIPYSRKWEFVSAFRQAQRQENALAIVNSGMRVFFGEGD
GIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNEVSL
LGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDDPIGHPIMHLSGVKH
ATGEAIYCDDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIM
TAEHFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTI
EESPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGE
DQEMDVYVSTQFPKYIQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTG
IIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYKAGFMNDGRI
LALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKFPNLRCRGWACRTNLP
SNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYK
QEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFP
VGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRM
PMSNVHLRGTSTETVPNANISGGSVVADLNGLAVKDACQTLLKRLEPIIS
KNPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWEKGEGQPFEYFVYG
AACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLY
TIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSNTLYSS
KGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMAC
EDKFTKMIPRDEPGSYVPWNV
3D structure
PDB8emt Cryo-EM analysis of the human aldehyde oxidase from liver
ChainB
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.17.3.-
1.2.3.1: aldehyde oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FES B C114 C117 C149 C151 C109 C112 C144 C146
BS02 FES B G43 C44 G45 G47 C49 G50 C52 C74 G38 C39 G40 G42 C44 G45 C47 C69
BS03 FAD B P263 V264 M266 G267 T269 S270 V271 L344 A345 A353 G357 H358 I360 D367 P210 V211 M213 G214 T216 S217 V218 L291 A292 A300 G304 H305 I307 D314
Gene Ontology
Molecular Function
GO:0004031 aldehyde oxidase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051287 NAD binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0071949 FAD binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006805 xenobiotic metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8emt, PDBe:8emt, PDBj:8emt
PDBsum8emt
PubMed37289586
UniProtQ06278|AOXA_HUMAN Aldehyde oxidase (Gene Name=AOX1)

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