Structure of PDB 8eme Chain B

Receptor sequence
>8emeB (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT
SPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDY
VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV
KITDFGPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPA
SEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSK
MARDPQRYLVIQGLPSPTDSNFYRALMDEEDM
3D structure
PDB8eme Dual-covalency small molecule inhibitors of the epidermal growth factor kinase
ChainB
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZNL B L718 V726 C775 M790 M793 P794 G796 C797 D800 R841 L844 T854 L17 V25 C74 M89 M92 P93 G95 C96 D99 R140 L143 T153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8eme, PDBe:8eme, PDBj:8eme
PDBsum8eme
PubMed38947214
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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