Structure of PDB 8eix Chain B

Receptor sequence
>8eixB (length=374) Species: 9796 (Equus caballus) [Search protein sequence]
STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRADD
HVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKC
RVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYT
VVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGL
GGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPI
QEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN
LSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVL
PFEKINEGFDLLRSGESIRTILTF
3D structure
PDB8eix Structure of cobalt(II)-substituted S48A horse liver alcohol dehydrogenase at 2.46 Angstroms resolution
ChainB
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO B C46 H67 C174 C46 H67 C174
BS02 ZN B C97 C100 C103 C111 C97 C100 C103 C111
BS03 NAI B R47 T178 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 R47 T178 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318
BS04 CXF B A48 H67 F93 C174 V294 A48 H67 F93 C174 V294
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8eix, PDBe:8eix, PDBj:8eix
PDBsum8eix
PubMed37563323
UniProtP00327|ADH1E_HORSE Alcohol dehydrogenase E chain

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