Structure of PDB 8eik Chain B

Receptor sequence
>8eikB (length=438) Species: 9606 (Homo sapiens) [Search protein sequence]
RGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCR
DRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVG
TGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYE
APKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEE
SIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNP
ARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRD
ISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDC
LEYNRIAKLKKVQTITKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHY
TDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB8eik Cryo-EM structure of human DNMT3B homo-hexamer
ChainB
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B F581 S604 E605 D627 V628 R832 S833 W834 F172 S195 E196 D218 V219 R417 S418 W419
BS02 ZN B C438 C455 C458 C29 C46 C49
BS03 ZN B C478 C481 C500 C69 C72 C91
BS04 ZN B C490 C495 C527 C81 C86 C118
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:8eik, PDBe:8eik, PDBj:8eik
PDBsum8eik
PubMed37941146
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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