Structure of PDB 8eic Chain B

Receptor sequence
>8eicB (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB8eic Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainB
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T26 M50 L54 G58 I61 Q72 V93 H96 Y100 Y104 T2 M26 L30 G34 I37 Q48 V69 H72 Y76 Y80
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:8eic, PDBe:8eic, PDBj:8eic
PDBsum8eic
PubMed37914719
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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