Structure of PDB 8ei7 Chain B

Receptor sequence
>8ei7B (length=370) Species: 9606 (Homo sapiens) [Search protein sequence]
PDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL
RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQ
INPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPT
LKDLESIDPEFYNSIVWIKENGLELYFIQDMEILGKVTTHELKEGGESIR
VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKEL
ELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLL
QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLP
PYKSYEQLREKLLYAIEETE
3D structure
PDB8ei7 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainB
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E552 L554 E62 L64
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei7, PDBe:8ei7, PDBj:8ei7
PDBsum8ei7
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

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