Structure of PDB 8ei1 Chain B

Receptor sequence
>8ei1B (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
DETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQI
CEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRT
YVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAI
DRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEY
LHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNN
LLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK
TMRQELDDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPN
3D structure
PDB8ei1 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainB
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide B V488 P491 M497 R498 L501 D502 K505 K527 F530 F533 R537 P538 V293 P296 M302 R303 L306 D307 K310 K332 F335 F338 R342 P343
Gene Ontology
Molecular Function
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

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Molecular Function

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Biological Process
External links
PDB RCSB:8ei1, PDBe:8ei1, PDBj:8ei1
PDBsum8ei1
PubMed37914719
UniProtQ13620|CUL4B_HUMAN Cullin-4B (Gene Name=CUL4B)

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