Structure of PDB 8ehp Chain B

Receptor sequence
>8ehpB (length=765) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
SILHSEIGRLNNQSLLWGPYRPNIYFGTRPRIGKSLMTGLMWGKIESYTD
FQHTVRYTCEQNEGMKGYGWDEYDPRRGGIQSIHDIQNGLDITTSFVKIP
GGAHGGSWAARIKGTLNDDAPKDQKTIVVFYVSQEGENSELEAVPSENEF
GYEGDVILKGRSEALGNYKLVVTKGKGVIPQSDHDLSRLRGPGQTVVQSL
TYPDEVLWQAKPILFQQLKAGIDWLVENKYDVADPPPPWQVYLLANKPGS
GNVHIVQKVFEGDFEFDILFSSESAGKEVTSKDLEREVKQATEVFGERFA
RVFDLKAPFQGDNYKKFGKSMFSNLIGGIGYFYGHSLVDRSYAPEYDEEN
EGFWEDAAEARARHQEALEGPYELFTSIPSRPFFPRGFLWDEGFHLLPIA
DWDIDLALEIIKSWYNLMDEDGWIAREQILGAEARSKVPKEFQTQYPHYA
NPPTLFLVLDNFVERLRKNNTLSTASVDNPEVGLEYLRRLYPLLRRQFDW
FRKTQAGDIKSYDREAYSTKEAYRWRGRTVSHCLTSGLDDYPRPQPPHPG
ELHVDLMSWVGVMVKSLISIGSLLGATEDVEFYTKVLDAIEHNLDDLHWS
EKEGCYCDATIDEFEEHKLVCHKGYISLFPFLTGLLKPDSPKLGKLLALI
GDESELWSPYGLRSLSKKDEFYGTAENYWRSPVWININYLAIVQLYNIAT
QDGPYKETARDLYTRLRKNIVETVYRNWEETGFAWEQYNPETGKGQRTQH
FTGWTSLVVKIMSGH
3D structure
PDB8ehp Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.
ChainB
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.106: mannosyl-oligosaccharide glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WJO B P412 F417 F421 W423 D424 F475 G584 D586 Y725 P379 F384 F388 W390 D391 F442 G537 D539 Y678
Gene Ontology
Molecular Function
GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006487 protein N-linked glycosylation
GO:0009311 oligosaccharide metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ehp, PDBe:8ehp, PDBj:8ehp
PDBsum8ehp
PubMed36762932
UniProtG0SFD1

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