Structure of PDB 8eew Chain B

Receptor sequence
>8eewB (length=766) Species: 9606 (Homo sapiens) [Search protein sequence]
ATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELR
KLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVV
GDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDS
SREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRM
VLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAE
RSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMK
ALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNL
SLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELF
EKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTM
NSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHD
DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAA
IYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNE
LEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRH
FLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTL
RQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVRE
IQEKLDAFIEALHQEK
3D structure
PDB8eew OPA1 helical structures give perspective to mitochondrial dysfunction.
ChainB
Resolution5.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B A299 G300 T302 S303 P315 R316 G317 M322 T323 K468 G504 K505 A105 G106 T108 S109 P121 R122 G123 M128 T129 K274 G310 K311
BS02 ALF B D296 Q297 K301 M321 T323 D102 Q103 K107 M127 T129
BS03 MG B K301 T323 K107 T129
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:8eew, PDBe:8eew, PDBj:8eew
PDBsum8eew
PubMed37612506
UniProtO60313|OPA1_HUMAN Dynamin-like GTPase OPA1, mitochondrial (Gene Name=OPA1)

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