Structure of PDB 8ed7 Chain B

Receptor sequence

>8ed7B (length=957) Species: 10090 (Mus musculus)

ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQ
LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTG
VIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRI
GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGH
KYSEVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDL
AILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAM
LDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR
DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLNHFP
FPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASEN
DMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNA
TCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPP
SILSLEFKNGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP
STQEWIVISYIFTLGIEKMREILMSGKLLQKVKVWLQEYWNVTDLIAILL
FSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMI
GKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWM
IYGEVFADQIKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI
SNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCRDYGLKLFIT
DDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEE
VNEREHS

3D structure

• PDB: 8ed7 Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
• Chain: B
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	T133 Q134 L135 S136 P137 T138 R159 S161 E176	T5 Q6 L7 S8 P9 T10 R31 S33 E48
BS02	9Z9	B	M887 Y983	M636 Y730
BS03	9Z9	B	M1022 P1038 S1039 W1040	M769 P785 S786 W787

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8ed7, PDBe:8ed7, PDBj:8ed7
• PDBsum: 8ed7
• PubMed: 36283409
• UniProt: Q5F4S7