Structure of PDB 8ebl Chain B

Receptor sequence
>8eblB (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
ACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETG
RWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRST
DRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFE
FDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATV
GNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPV
SSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACA
SDEGEVIVFGGCANNLLVHHRAAHSNEILIFSV
3D structure
PDB8ebl E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
ChainB
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y50 H109 K147 Y163 S185 R189 R236 R241 S269 W270 H345 Y24 H83 K121 Y137 S159 R163 R210 R215 S243 W244 H319
External links
PDB RCSB:8ebl, PDBe:8ebl, PDBj:8ebl
PDBsum8ebl
PubMed36805027
UniProtQ9Y2U9|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)

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