Structure of PDB 8eaz Chain B

Receptor sequence
>8eazB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
VQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRN
SQEAEVSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDLGISIAENRS
AFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIHEQMNCKEYQ
EDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQKKDGADWIRC
TVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
3D structure
PDB8eaz The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
ChainB
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C282 C285 C305 C308 C17 C20 C40 C43
BS02 ZN B C300 H302 C323 C332 C35 H37 C58 C67
BS03 ZN B C371 C376 C391 C394 C106 C111 C126 C129
BS04 ZN B C399 H406 C411 C134 H141 C146
BS05 ZN B C447 C450 C465 C182 C185 C200
BS06 ZN B C473 C493 C502 C509 C208 C228 C237 C244
BS07 ZN B C495 C502 C506 C230 C237 C241
External links
PDB RCSB:8eaz, PDBe:8eaz, PDBj:8eaz
PDBsum8eaz
PubMed36631489
UniProtQ9BYM8|HOIL1_HUMAN RanBP-type and C3HC4-type zinc finger-containing protein 1 (Gene Name=RBCK1)

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