Structure of PDB 8eaj Chain B

Receptor sequence
>8eajB (length=589) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]
QIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFN
ENLAYEIINNTKIILPILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRV
IELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWP
EDEEMPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPS
GQLPRQLEIILEDDLVDSARPGDRVKVTGILDIKQDSPVKRGSRAVFDIY
MKVSSIEVSSEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALAL
ALFGGVPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRAVYTTG
KGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRV
AIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNIN
LPPTILSRFDLIFILKDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRK
YIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPILITPRQLEAL
IRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDM
3D structure
PDB8eaj Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T369 V377 R379 Y386 A431 T354 V362 R364 Y371 A416
BS02 08T B R473 P559 R560 E563 R458 P544 R545 E548
BS03 ZN B H144 C149 C171 C174 H138 C143 C165 C168
BS04 08T B Y304 P342 G343 T344 A345 K346 S347 Q348 L491 Y289 P327 G328 T329 A330 K331 S332 Q333 L476
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:8eaj, PDBe:8eaj, PDBj:8eaj
PDBsum8eaj
PubMed36499022
UniProtQ9UXG1|MCM_SACS2 Minichromosome maintenance protein MCM (Gene Name=MCM)

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