Structure of PDB 8e94 Chain B

Receptor sequence
>8e94B (length=642) Species: 9606 (Homo sapiens) [Search protein sequence]
TVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQ
ICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVL
TPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSR
EEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTES
WRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREA
FYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVL
YMKYPVWPRYSDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQS
NHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRV
RGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR
SDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKF
NQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFAT
TGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGIC
3D structure
PDB8e94 Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
ChainB
Resolution3.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IWB B P222 R467 P192 R430
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e94, PDBe:8e94, PDBj:8e94
PDBsum8e94
PubMed36309015
UniProtQ14957|NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C (Gene Name=GRIN2C)

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