Structure of PDB 8e90 Chain B

Receptor sequence
>8e90B (length=462) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKTAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSS
RELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGA
CQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAG
VAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLL
WLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYR
DEHIYPYIYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEF
FEVANDVIPNLLKEAASLLEAGEGSALQDPECFAHLLRFYDGICKWEEGS
PTPVLHVGWATFLVQSLGRFEGQVRQKVRITFQSEKMKGMKELLVATKIN
SSAIKLQLTAQS
3D structure
PDB8e90 MEN1 mutations mediate clinical resistance to menin inhibition.
ChainB
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OQ4 B S155 S178 E179 H181 A182 F238 C241 A242 Y276 M278 Y319 I322 Y323 G326 W341 S141 S164 E165 H167 A168 F224 C227 A228 Y262 M264 Y305 I308 Y309 G312 W327
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8e90, PDBe:8e90, PDBj:8e90
PDBsum8e90
PubMed36922589
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

[Back to BioLiP]