Structure of PDB 8e4x Chain B

Receptor sequence
>8e4xB (length=454) Species: 9606 (Homo sapiens) [Search protein sequence]
NPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLA
KARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGK
FGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMS
DRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGF
RLKENVQFHLYISTSPCGDARIFSPHEPIARGQLRTKIESGQGTIPVRSN
ASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSII
LGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAP
NFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSH
LLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQ
FSLT
3D structure
PDB8e4x ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B S258 H259 F263 R279 N280 K281 S24 H25 F29 R45 N46 K47
BS02 rna B N235 M238 K282 N1 M4 K48
BS03 IHP B I397 R401 K519 R522 S531 K629 Y658 K662 Y668 K672 E689 K690 I163 R167 K273 R276 S285 K383 Y412 K416 Y422 K426 E443 K444
BS04 ZN B H394 C451 C516 H160 C217 C270
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:8e4x, PDBe:8e4x, PDBj:8e4x
PDBsum8e4x
PubMed36243986
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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