Structure of PDB 8dyl Chain B

Receptor sequence
>8dylB (length=703) Species: 9606 (Homo sapiens) [Search protein sequence]
QQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSKRDTMDLPEEL
PGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLS
VAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVS
MTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPP
EPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGL
EYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEK
MFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSL
HTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLT
NDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEV
IVGVNKYQLEKDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTECAASG
DGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGES
KEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFD
VDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELNSLGR
PDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLE
KKQ
3D structure
PDB8dyl Bivalent molecular mimicry by ADP protects metal redox state and promotes coenzyme B 12 repair.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.4.99.2: methylmalonyl-CoA mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 B A160 V227 R228 E268 W356 E392 A393 L394 G395 G626 H627 D628 R629 G630 I634 S672 L674 A675 A676 G702 G703 F722 G723 T726 A125 V192 R193 E233 W321 E357 A358 L359 G360 G582 H583 D584 R585 G586 I590 S628 L630 A631 A632 G658 G659 F678 G679 T682
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003924 GTPase activity
GO:0004494 methylmalonyl-CoA mutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0016866 intramolecular transferase activity
GO:0031419 cobalamin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0072341 modified amino acid binding
Biological Process
GO:0006790 sulfur compound metabolic process
GO:0009791 post-embryonic development
GO:0019678 propionate metabolic process, methylmalonyl pathway
GO:0043547 positive regulation of GTPase activity
GO:0050667 homocysteine metabolic process
GO:1901290 succinyl-CoA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dyl, PDBe:8dyl, PDBj:8dyl
PDBsum8dyl
PubMed36888659
UniProtP22033|MUTA_HUMAN Methylmalonyl-CoA mutase, mitochondrial (Gene Name=MMUT)

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