Structure of PDB 8dso Chain B

Receptor sequence
>8dsoB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDE
FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRF
QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS
RYVVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF
TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI
LDVMDEES
3D structure
PDB8dso A covalent BTK ternary complex compatible with targeted protein degradation
ChainB
Resolution2.334 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TOO B L408 G409 Q412 V416 A428 K430 L460 T474 Y476 M477 G480 C481 N484 L528 D539 F540 L542 F559 L17 G18 Q21 V25 A37 K39 L69 T83 Y85 M86 G89 C90 N93 L135 D146 F147 L149 F158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8dso, PDBe:8dso, PDBj:8dso
PDBsum8dso
PubMed36864023
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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