Structure of PDB 8dsg Chain B

Receptor sequence
>8dsgB (length=451) Species: 1404 (Priestia megaterium) [Search protein sequence]
TIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTR
YLSSQRLIKEACDESRFDKTLSQGLKFLRDFLGDGLATSWTHEKNWKKAH
NILLPSFSQQAMKGYHASMVDIAVQLVQKWERLNADEHIEVSEDMTRLTL
DTIGLCGFNYRFNSFYRDQPHPFIISMVRALDEVMNKLQRANPDDPAYDE
NKRQFQEDIKVMNDLVDKIIADRKATDDLLTQMLNGKDPETGEPLDDGNI
RYQIITFLYAGVEGTSGLLSFALYFLVKNPHVLQKVAEEAARVLVDPVPS
YKQVKQLKYVGMVLNEALRLWPVVPVFSLYAKEDTVLGGEYPLEKGDEVM
VLIPQLHRDKTVWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRASPGQQ
FALHEATLVLGMMLKHFDFEDHTNYELDIKELQTLKPKGFVVKAKSKKIP
L
3D structure
PDB8dsg Chemodivergent C(sp3)-H and C(sp2)-H cyanomethylation using engineered carbene transferases
ChainB
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
1.6.2.4: NADPH--hemoprotein reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B K69 L86 A87 W96 F261 A264 V328 F331 P392 F393 G394 R398 S400 P401 G402 A406 K69 L86 A87 W96 F257 A260 V324 F327 P388 F389 G390 R394 S396 P397 G398 A402
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:8dsg, PDBe:8dsg, PDBj:8dsg
PDBsum8dsg
PubMed36875868
UniProtP14779|CPXB_PRIM2 Bifunctional cytochrome P450/NADPH--P450 reductase (Gene Name=cyp102A1)

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