Structure of PDB 8dsf Chain B

Receptor sequence
>8dsfB (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
ISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCD
GGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY
3D structure
PDB8dsf A covalent BTK ternary complex compatible with targeted protein degradation
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C306 C309 H326 C333 C46 C49 H66 C73
BS02 TO0 B D303 G312 L313 R314 C315 D320 W329 D43 G52 L53 R54 C55 D60 W69
External links
PDB RCSB:8dsf, PDBe:8dsf, PDBj:8dsf
PDBsum8dsf
PubMed36864023
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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