Structure of PDB 8dnj Chain B

Receptor sequence
>8dnjB (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB8dnj Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors.
ChainB
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G13 V14 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 L120 S145 A146 G14 V15 G16 K17 S18 A19 F29 V30 D31 N117 K118 D120 L121 S146 A147
BS02 U4U B G10 C12 K16 T58 A59 G60 E63 Y64 R68 M72 Y96 Q99 G11 C13 K17 T59 A60 G61 E64 Y65 R69 M73 Y97 Q100
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8dnj, PDBe:8dnj, PDBj:8dnj
PDBsum8dnj
PubMed35930206
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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