Structure of PDB 8dgz Chain B

Receptor sequence
>8dgzB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
RDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCF
RSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIY
GKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACDGIIPVEADFLFAYS
TVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFP
HFHEKKQIPCVVSMLTKELYFSQ
3D structure
PDB8dgz Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N88 H144 Q184 A185 C186 Y230 S231 W232 R233 S234 P235 W240 N37 H93 Q133 A134 C135 Y156 S157 W158 R159 S160 P161 W166
BS02 8YJ B N148 T163 A164 E216 F219 M294 N97 T112 A113 E142 F145 M214
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0009411 response to UV
GO:0016485 protein processing
GO:0030163 protein catabolic process
GO:0042742 defense response to bacterium
GO:0043525 positive regulation of neuron apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0051146 striated muscle cell differentiation
GO:0051402 neuron apoptotic process
GO:0051604 protein maturation
GO:0070227 lymphocyte apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071887 leukocyte apoptotic process
GO:0072734 cellular response to staurosporine
GO:0097194 execution phase of apoptosis
GO:1905686 positive regulation of plasma membrane repair
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dgz, PDBe:8dgz, PDBj:8dgz
PDBsum8dgz
PubMed37005499
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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