Structure of PDB 8dgq Chain B

Receptor sequence
>8dgqB (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
STAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLS
QMNVVNHFRIIAMSGDYYIGGRRFSSLSDLIGYYSHVSSLLKGEKLLYPV
APPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTN
LRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVS
SFLVRPSDNTPGDYSLYFRTNENIQRFKISPTPNNQFMMGGRYYNSIGDI
IDHYRKEQIVEGYYLKEPVPM
3D structure
PDB8dgq Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R188 R207 V217 H229 F230 R231 G242 R244 Y255 S260 S261 L262 S379 S387 R398 F399 K400 G412 G413 R414 H425 Y426 Q430 I431 E433 R16 R35 V45 H57 F58 R59 G70 R72 Y83 S88 S89 L90 S207 S215 R226 F227 K228 G240 G241 R242 H253 Y254 Q258 I259 E261
External links
PDB RCSB:8dgq, PDBe:8dgq, PDBj:8dgq
PDBsum8dgq
PubMed36417908
UniProtP20936|RASA1_HUMAN Ras GTPase-activating protein 1 (Gene Name=RASA1)

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