Structure of PDB 8d81 Chain B

Receptor sequence
>8d81B (length=381) Species: 9606 (Homo sapiens) [Search protein sequence]
NIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPG
QTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAY
REEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTM
SAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWL
YSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVL
RIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCG
PMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKIC
ASHIGWKFTATKKDMSPQKFWGLTRSALLPT
3D structure
PDB8d81 Molecular glue CELMoD compounds are regulators of cereblon conformation.
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C391 C394 C347 C350
BS02 Y70 B H353 H378 S379 W380 W386 W400 H309 H334 S335 W336 W342 W356
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0035641 locomotory exploration behavior
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902607 negative regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d81, PDBe:8d81, PDBj:8d81
PDBsum8d81
PubMed36378961
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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