Structure of PDB 8d7u Chain B

Receptor sequence
>8d7uB (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
KKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMIL
IPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEI
YAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLP
STMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWP
RWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPID
DVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLS
LCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQC
KICASHIGWKFTATKKDMSPQKFWGLTRSALLPT
3D structure
PDB8d7u Molecular glue CELMoD compounds are regulators of cereblon conformation.
ChainB
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C323 C326 C391 C394 C282 C285 C350 C353
BS02 QFC B F102 F150 N351 P352 H378 S379 W380 W386 F402 F61 F109 N310 P311 H337 S338 W339 W345 F361
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0035641 locomotory exploration behavior
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902607 negative regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8d7u, PDBe:8d7u, PDBj:8d7u
PDBsum8d7u
PubMed36378961
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

[Back to BioLiP]