Structure of PDB 8d6e Chain B

Receptor sequence
>8d6eB (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
LQPRRVSFRGEASEPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSK
EDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLV
HLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQ
GSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSS
ELRSVLVMMLEPDPKLRATAEALLALPVLRQ
3D structure
PDB8d6e Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QGI B V124 T187 C190 F240 D251 V44 T107 C110 F160 D171
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d6e, PDBe:8d6e, PDBj:8d6e
PDBsum8d6e
PubMed35880755
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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