Structure of PDB 8d6c Chain B

Receptor sequence
>8d6cB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
LQPRRVSFRGEASETSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVR
SKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWE
EGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQG
LVHLDVKPANIFLGPRGRCKLGDFGLLVELGTGEVQEGDPRYMAPELLQG
SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSE
LRSVLVMMLEPDPKLRATAEALLALPVLR
3D structure
PDB8d6c Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QGR B V124 K139 T187 E188 L189 C190 F240 D251 V46 K61 T109 E110 L111 C112 F162 D173
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d6c, PDBe:8d6c, PDBj:8d6c
PDBsum8d6c
PubMed35880755
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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