Structure of PDB 8d40 Chain B

Receptor sequence

>8d40B (length=427) Species: 9606 (Homo sapiens)

SGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGL
FDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATT
YITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINAN
LRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPG
PLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRD
QGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ
DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHI
QAVDADSGENARLHYRLVDTAPDFPFQIHNSSGWITVCAELDREEVEHYS
FGVEAVDHGSPPMSSSTSVSITVLDVN

3D structure

• PDB: 8d40 Crystal structure of human CELSR1 EC1-4
• Chain: B
• Resolution: 3.554 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	E21 E79 D110 T111 D113 D146	E19 E77 D108 T109 D111 D144
BS02	CA	B	N112 H114 D144 D146 D196	N110 H112 D142 D144 D194
BS03	CA	B	E129 R182 E183 D216 E217 D219 D252	E127 R180 E181 D214 E215 D217 D250
BS04	CA	B	N218 N220 D250 D252 N256 D303	N216 N218 D248 D250 N254 D301
BS05	CA	B	E235 D288 E290 D325	E233 D286 E288 D323
BS06	CA	B	E235 E290 D322 V323 D325 D358	E233 E288 D320 V321 D323 D356
BS07	CA	B	N324 N326 D356 D358 D426	N322 N324 D354 D356 D407

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8d40, PDBe:8d40, PDBj:8d40
• PDBsum: 8d40
• UniProt: Q9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)