Structure of PDB 8d3k Chain B

Receptor sequence
>8d3kB (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
APSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSK
ELWFSDDPNVTKTLRFKGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTG
KKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSR
TTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEV
IQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLL
IKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR
SNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQS
MFWSDLGPDVGYEAIGLVDSSLPTVGVFAGKGVIFYLRDKVVVGIVLWNI
FNRMPIARKIIKDGEQHEDLNEVAKLFNIHLEVLFQ
3D structure
PDB8d3k Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QC6 B F310 L311 E314 W483 S484 F180 L181 E184 W353 S354
BS02 FAD B G138 G139 A142 E164 R172 P173 K177 K232 V233 T260 F284 R285 G437 D438 H454 H455 A458 W483 G11 G12 A15 E37 R45 P46 K50 K102 V103 T130 F154 R155 G307 D308 H324 H325 A328 W353
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3k, PDBe:8d3k, PDBj:8d3k
PDBsum8d3k
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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