Structure of PDB 8d3i Chain B

Receptor sequence
>8d3iB (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]
PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKE
LWFSDDPNVTKTLRFKQANGKERSIYFQPPSFYVSAQDLPHIENGGVAVL
TGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVK
SRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGT
EVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGK
LLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQ
ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH
QSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKGVIFYLRVVVGIVLWNIF
NRMPIARKIIKDGEQHEDLNEVAKLFNIH
3D structure
PDB8d3i Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainB
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1LM B F310 L311 E314 W483 F182 L183 E186 W355
BS02 FAD B G138 T141 A142 E164 D165 R172 P173 S176 K177 K232 V233 T260 F284 R285 G437 D438 E453 H454 H455 A458 W483 G10 T13 A14 E36 D37 R44 P45 S48 K49 K104 V105 T132 F156 R157 G309 D310 E325 H326 H327 A330 W355
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3i, PDBe:8d3i, PDBj:8d3i
PDBsum8d3i
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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