Structure of PDB 8d3g Chain B

Receptor sequence
>8d3gB (length=432) Species: 9606 (Homo sapiens) [Search protein sequence]
PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKE
LWFSDDPNVTKTLRFKQKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGK
KVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRT
TLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVI
QLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLI
KLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARS
NIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSM
FWSDLGYEAIGLVDSSLPTVGVFAKGVIFYLRDKVVVGIVLWNIFNRMPI
ARKIIKDGEQHEDLNEVAKLFNIHEDLEVLFQ
3D structure
PDB8d3g Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainB
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G138 G139 G140 A142 E164 R172 P173 K177 K232 V233 T260 F284 R285 G437 D438 H454 H455 A458 G10 G11 G12 A14 E36 R44 P45 K49 K101 V102 T129 F153 R154 G306 D307 H323 H324 A327
BS02 QD1 B F310 L311 E314 H454 F482 F179 L180 E183 H323 F351
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3g, PDBe:8d3g, PDBj:8d3g
PDBsum8d3g
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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