Structure of PDB 8d3e Chain B

Receptor sequence
>8d3eB (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
DKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPL
SKELWFSDDPNVTKTLRFKQANGKERSIYFQPPSFYVSAQDLPHIENGGV
AVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGA
EVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARA
LGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVS
SGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNA
ELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKP
YWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKGKGVIFYLRDKVVVG
IVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIH
3D structure
PDB8d3e Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainB
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G138 G140 A142 E164 D165 R172 P173 K177 K232 V233 T260 F284 R285 G437 D438 E453 H454 H455 A458 F482 W483 G13 G15 A17 E39 D40 R47 P48 K52 K107 V108 T135 F159 R160 G312 D313 E328 H329 H330 A333 F357 W358
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3e, PDBe:8d3e, PDBj:8d3e
PDBsum8d3e
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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