Structure of PDB 8d0h Chain B

Receptor sequence
>8d0hB (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
TPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQS
VMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGF
EWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQ
3D structure
PDB8d0h Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
ChainB
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q1O B S567 Y568 R569 R570 D594 V595 F603 W638 E642 S7 Y8 R9 R10 D34 V35 F43 W78 E82
Gene Ontology
Molecular Function
GO:0003953 NAD+ nucleosidase activity
GO:0035591 signaling adaptor activity
Biological Process
GO:0007165 signal transduction
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0048678 response to axon injury

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Molecular Function
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Biological Process
External links
PDB RCSB:8d0h, PDBe:8d0h, PDBj:8d0h
PDBsum8d0h
PubMed36087583
UniProtQ6SZW1|SARM1_HUMAN NAD(+) hydrolase SARM1 (Gene Name=SARM1)

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