Structure of PDB 8cwo Chain B

Receptor sequence
>8cwoB (length=233) Species: 1747 (Cutibacterium acnes) [Search protein sequence]
MAVVTTRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLHQSLTYI
DKAYAFVKETVAKGGQILFVGTKKQAQESIVEQATRVGMPYVNQRWLGGM
LTNFQTISKRIARLKELEAMDFDKVSGSGLTKKELLMLSREKDKLEKDLG
GIRDMPKVPQAVWVVDTKKEHLAIDEARKLKIPVVAILDTNCDPDEVDYA
IPGNDDAIRSVSLLTRIIADAAAEGLMARSAGK
3D structure
PDB8cwo Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
ChainB
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B T20 R21 W23 P25 K28 T20 R21 W23 P25 K28
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8cwo, PDBe:8cwo, PDBj:8cwo
PDBsum8cwo
PubMed36864821
UniProtQ6A7J7|RS2_CUTAK Small ribosomal subunit protein uS2 (Gene Name=rpsB)

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