Structure of PDB 8cvx Chain B

Receptor sequence
>8cvxB (length=603) Species: 9606 (Homo sapiens) [Search protein sequence]
DLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQG
VRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGAS
AWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEK
PHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYN
NLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKR
KPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDK
TLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPART
NNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDK
EDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADR
VKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVM
GIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLY
SFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFT
YEP
3D structure
PDB8cvx The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.11: glycogen(starch) synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6P B Q294 H297 K301 H501 R579 R582 R586 Q272 H275 K279 H479 R557 R560 R564
Gene Ontology
Molecular Function
GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
Biological Process
GO:0005978 glycogen biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8cvx, PDBe:8cvx, PDBj:8cvx
PDBsum8cvx
PubMed35793618
UniProtP13807|GYS1_HUMAN Glycogen [starch] synthase, muscle (Gene Name=GYS1)

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