Structure of PDB 8cro Chain B

Receptor sequence
>8croB (length=1098) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
DVTPDDLWIVMESYWQEKGLVRQHLDSYNAFIERGLQEVVNEFGGIKPDI
PDFEVKFGKIRVGEPEFQEPHGQRKPLYPMDARIRNLTYAAPLYLEMIPV
IKGVEQDPVEVRIGELPIMLKSKVCRLYGLSDEELIKLGEDPKDPGGYFI
INGSERVIVSIEDIAPNRTLVEKDERQEKYIAKVFSYRHGYRALVAVERR
KDGILYVDIPNVPKPVKFVYVMRALGLERDKDIVEAVGNDPEVQQIMFDN
LEDASDITTQQEALEFIGKLVAPGQAREYRLKRAEYVIDNNLLPHMGVSP
EDRIKKAYYLGMMALKVIELSLGRRPEDDKDHYANKRLRLAGDLLKDLFR
VAFSQLVKDIQYQMTKTYQRKGDKYTFGNIHRFIRNSIRPDVLTERIEHA
LATGAWPGGRTGVSQLLDRTNYMSTLSHLRRVTSPLDREQPHFEARDLHG
THWGRICPTETPEGPNCGLVKNLALMAQITTAVPEEEIREYLMSLGIVPI
EVRRPDPTLWRVYLNGVLIGTIEDGKALVQRIRQDRRSGKISDVINVAYY
EDVKEVYVNSDDGRVRRPLIIVENGVPKLTKEHVQAVKEGRLKWSDLIKM
GIIEYLDAEEEENAYVAMWPWEVTEEHTHLELMPAAILGLPASLVPYPEH
NAAPRNTYGAGMAKQSLGLGWANFRIRVDTRGHLLHYPQIPLVNSRIMKA
VGYEDRPAGQNFVVAVLAYQGYNMEDAIIINKASIERGLARSTFFRTYEA
EEKKYLGGQTDKFEIPDPTVRGYRGEKYYRNLDEDGLIFPESKVEGKDVL
VGRTSPPRFLERRETSVAVRPSEKGVVDKVIITETGDGTKLVKVTVRDLR
IPELGDKFASRHGQKGVIGLIVPQEDMPWTESGIVPDLIVNPHGIPSRMT
VGQLIEAIGGKVASLKGRRVDGTAFIGEPEEKLRKELEELGFKHTGREIM
YDGITGKRLEADIFIGVIYYQRLHHMVADKIHARSRGPVQVLTKQPTEGR
AREGGLRFGEMERDVLVGHGAAMLLIERLLEESDKTEVWVCENCGHIALE
DKRRRRVYCPVCGEEERISKVEMSYAFKLLLDELKAMVIRPKLNLSER
3D structure
PDB8cro Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T687 R688 R753 R838 R1018 R1025 T680 R681 R746 R820 R1000 R1007
BS02 rna B Q422 Q672 K875 K883 H993 Q1008 Q415 Q665 K857 K865 H975 Q990
BS03 ZN B C1059 C1062 C1077 C1080 C1041 C1044 C1059 C1062
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cro, PDBe:8cro, PDBj:8cro
PDBsum8cro
PubMed38709902
UniProtQ8U0M3

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