Structure of PDB 8cp6 Chain B

Receptor sequence

>8cp6B (length=1084) Species: 287 (Pseudomonas aeruginosa)

PVNPMLGSKLLPEEVDFALAAPDTFTFARGYLSSNPRIGRLGRGWWLPGE
SMHLELSEDACVLVDAQGRRIGFPALAPGAQHYSGSEELWLRRGGSSGGE
AQAWRGRWAAVPAELQTQEGSVLVLSGHSYLHFQRCPDGIWRLQASFGRA
GYRTEFRWSGRGLLTGVRDSAGRSYALVYQQACEPSEGDDGLRLFGVILA
SHDGPPPDYIDPQSPGLDWLVRYQFSDSGDLIAVRDRLGQVVRVFAWREH
MLVAHGEPGGLEVRYEWDVHAPHGRVVKQIEAGGLTRTFRYLRDATEVSD
SLGRVERYEFAGEGGQRRWTALVRADGSRSEFDYDLFGRLVAMRDPLGRE
TRRRRDGQGRMLEEESPGKARYRKRVDEETGLLVELEDAMQRRWTFERDE
RGNATTVRGPAGSTRYAYEDPRLPDRPTRIVDPRGGERRLEWNRFGLLAA
LTDCSGQVWRYDYDNEGRLVASSDPLGQLTRRRYDPLGQLIGLELADGSA
LSYEYDALGRQTRIADAEGHATLFSWGHGDLLARVSDAGGGELSYLHDEA
GRLVALTNENGVQAQFRYDLLDRLVEETGFDGRRQRYRYNAADELIARED
ADGRETTYAYDRDGRLASIRVPATEHAPALVERYRWLADGRLASAGGADC
EVRYTYDEVGNLRLESQVHADGWVYSVEHSHDALGVRQTSRYGDAPPVAW
LTYGPGHLHGALVGAVELAFERDALHREVRRDARRDGQDDALFTQERQHA
PLGRLQRSRLRLAGGFDWQRGYRYDGLGQLVGIDDNQYPSVRYEYDLGGR
LLASRRAGAAASTYRYDAAGNRLEGARWAGNRVERIAGNRYRFDALGNLV
ERIGADGERLRLAYDGAQRLVHLTRDYADGTRLEARYRYDALSRRIAKVV
LRDGVEQQVRFGWDGDRQCAEAFARELRTTVHEPGGFVPLLRLEQACEPD
PPELLQLRQAFAAEGQPLPAQCVPALGEARIAFFHTDHLGTPLQLSDERG
QLRWQGVPDDWRAVAPERQPGAQPIRFQGQYHDEESGLYYNRYRYYLPEA
GRYASQDPLGLGGGPNPYAYALNAPTLAYDPTGL

3D structure

• PDB: 8cp6 Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane.
• Chain: B
• Resolution: 2.45 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	P48 V49 N50 P51 M52 L53 L57 L79 Q114 G115 R116 R117 I118 G119 F120 S131 Y312 Q326 R334 Y355 R364 W366	P1 V2 N3 P4 M5 L6 L10 L32 Q67 G68 R69 R70 I71 G72 F73 S84 Y265 Q279 R287 Y308 R317 W319
BS02	peptide	B	Q558 R801 Y821 L1156 L1161 A1162 Y1163 D1164	Q511 R754 Y774 L1072 L1077 A1078 Y1079 D1080

External links

• PDB: RCSB:8cp6, PDBe:8cp6, PDBj:8cp6
• PDBsum: 8cp6
• PubMed: 38016939
• UniProt: Q9I0F4|TSE5_PSEAE Toxin protein Tse5 (Gene Name=tse5)