Structure of PDB 8cp2 Chain B

Receptor sequence

>8cp2B (length=600) Species: 1424099 (Streptomyces sp. V2)

MPLSVAVVGAGPRGTSVLERLCASAPELLAPGVRLTVHVVDPAPPGPGRV
WRTAQSEDLLMNTVASQVTLFTDESVNCSGPILAGPSLHEWADGAIGPDD
YPTRALYGRYLEWVFARTLRHAPPSVRVETHRARAVRLDDAADGRQHLAL
DNGRTLTGLSAVVLAQGHLPVRPSAAVLRDTEHADRHALRHIPPANPADV
DLTVISPGEPVLLRGLGLNFFDHMALLTTGRGGTYVREDGVLRYVPSGRE
PRVYAGSRRGLPYQARGDNAKGPYGRHLPEVLTPEAVSAFRKRADSGEAP
DFLRDIWPLVAKEVETVYYTALVRHPDFAPRYLSLPYGDPQEAELLAEFG
VDADARWDWERVSRPYAQREFAHRGEWRQWLLGYLRADAAEALRGNVDGP
LKAALDVLRDLRNELRLVVDHRGLRGDSRRDHLDRWYTPLNAFLSIGPPR
RRIEELTALLEAGVVEVLGPRLEVTREDGAWLARSPDVPGSAVRVTTLIE
ARLPEPDLGQTADALLAHLRETGQCRAHVVDGYTTGGIDVSARPYHLVDR
EGVAHPRRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAVLRVAG

3D structure

• PDB: 8cp2 A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center.
• Chain: B
• Resolution: 2.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	V8 G9 P12 R13 V40 D41 P42 G48 V50 W51 M61 R134 A135 Q166 G167 H168 L169 N196 A573 A574 G575	V8 G9 P12 R13 V40 D41 P42 G48 V50 W51 M61 R134 A135 Q166 G167 H168 L169 N196 A573 A574 G575
BS02	NAP	B	L60 M61 N62 R104 G215 L216 G217 L218 N219 D222 S257 R258 R259 Y263 R502 L503	L60 M61 N62 R104 G215 L216 G217 L218 N219 D222 S257 R258 R259 Y263 R502 L503
BS03	ASP	B	R412 N413 R416 R577 S582 V583	R412 N413 R416 R577 S582 V583

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding

External links

• PDB: RCSB:8cp2, PDBe:8cp2, PDBj:8cp2
• PDBsum: 8cp2
• PubMed: 37302552
• UniProt: A0A2V1NMV1