Structure of PDB 8coz Chain B

Receptor sequence
>8cozB (length=335) Species: 5855 (Plasmodium vivax) [Search protein sequence]
KFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPDLR
NNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVSNSGDPMDDNYHGTHVS
GIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCISRQ
AHMISGSFSFDEYSNIFSASVEHLRSLGILFFVSASNCAHDDIAKCDLAV
NHRYPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPGTN
IYSTTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRNAI
VKLPSLTERVSWGGYVDILRAVNLAIDSKAAPYIK
3D structure
PDB8coz 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.
ChainB
Resolution1.438 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.62: subtilisin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E336 R340 V343 D345 D352 E59 R63 V66 D68 D75
BS02 CA B E336 D344 D346 N348 V350 D353 E59 D67 D69 N71 V73 D76
BS03 CA B D281 D325 V383 N386 I388 I390 D4 D48 V106 N109 I111 I113
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8coz, PDBe:8coz, PDBj:8coz
PDBsum8coz
PubMed37428845
UniProtE6Y8B9

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