Structure of PDB 8coy Chain B

Receptor sequence

>8coyB (length=337) Species: 5855 (Plasmodium vivax) [Search protein sequence]

GYKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPD
LRNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVSNSGDPMDDNYHGTH
VSGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCIS
RQAHMISGSFSFDEYSNIFSASVEHLRSLGILFFVSASNCAHDDIAKCDL
AVNHRYPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPG
TNIYSTTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRN
AIVKLPSLTERVSWGGYVDILRAVNLAIDSKAAPYIK

3D structure

PDB

8coy 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.

Chain

Resolution

1.507 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.4.21.62: subtilisin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	Y371 H372 L405 K409 G411 S434 F435 S436 N464 N546 G547 T548 S549	Y96 H97 L130 K134 G136 S159 F160 S161 N189 N266 G267 T268 S269
BS02	CA	B	D281 D325 V383 N386 I388 I390	D6 D50 V108 N111 I113 I115
BS03	CA	B	E336 R340 V343 D345 D352	E61 R65 V68 D70 D77
BS04	CA	B	E336 D344 D346 N348 V350 D353	E61 D69 D71 N73 V75 D78

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8coy, PDBe:8coy, PDBj:8coy
PDBsum	8coy
PubMed	37428845
UniProt	E6Y8B9

[Back to BioLiP]