Structure of PDB 8cls Chain B

Receptor sequence
>8clsB (length=853) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTE
VTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGL
HKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKEC
RLSKCPGEIRSCQLHNNRRLCWNSKLCQTKCPEKCRNNCIDEHTCCSQDC
LGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITL
TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG
LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQ
SSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGP
NQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGN
RGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAF
IGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYS
YYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWS
YLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVEYDDRKVQAGMEFE
NALQNFIFVPKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLR
HFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIV
MDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK
CIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPS
YAK
3D structure
PDB8cls Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.
ChainB
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R659 E660 H662 R309 E310 H312
BS02 peptide B S341 M342 D343 R345 F363 D367 L368 R393 S7 M8 D9 R11 F29 D33 L34 R59
BS03 peptide B N1041 F1044 P1046 N655 F658 P660
BS04 peptide B R848 E1036 Q1040 F1042 F1044 V1045 R498 E650 Q654 F656 F658 V659
External links
PDB RCSB:8cls, PDBe:8cls, PDBj:8cls
PDBsum8cls
PubMed37805602
UniProtP09208|INSR_DROME Insulin-like receptor (Gene Name=InR)

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