Structure of PDB 8cli Chain B

Receptor sequence
>8cliB (length=689) Species: 9606 (Homo sapiens) [Search protein sequence]
MVTRREPAVKLQYAVSGLEPLAWSEDHRVSVSTARSIAVLELICDVHNPG
QDLVIHRTSVPAPLNSCLLKVGSKTEVAECKEKFAASKDPTVSQTFMLDR
VFNPEGKALPPMRGFKYTSWSPMGCDANGRCLLAALTMDNRLTIQANLNR
LQWVQLVDLTEIYGERLYETSYRLSKNEAPEGNLGDFAEFQRRHSMQTPV
RMEWSGICTVGSVLLAVLFENGNIAVWQFQLPFVGKESISSCNTIESGIT
SPSVLFWWEYEHNNRKMSGLIVGSAFGPIKILPVNLKAVKGYFTLRQPVI
LWKEMDQLPVHSIKCVPLYHPYQKCSCSLVVAARGSYVFWCLLLISKAGL
NVHNSHVTGLHSLPIVSMTADKQNGTVYTCSSDGKVRQLIPIFTDVALKF
EHQLIKLSDVFGSVRTHGIAVSPCGAYLAIITTEGMINGLHPVNKNYQVQ
FVTLKTFEEAAAQLLESSVQNLFKQVDLIDLVRWKILKDKHIPQFLQEAL
EKKIESSGVTYFWRFKLFLLRILYQSMQKEPMEEKLLEIQGKIEAVEMHL
TREHMKRVLGEVYLHTWITENTSIPTRGLCNFLMSDEEYDDRTARVLIGH
ISKKMNKQTFPEHCSLCKEILPFTDRKQAVCSNGHIWLRCFLTYQSCQSL
IYRRCLLHDSIARHPAPEDPDWIKRLLQSPCPFCDSPVF
3D structure
PDB8cli Structural insights into human TFIIIC promoter recognition.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C747 C750 H768 C614 C617 H635
BS02 ZN B C788 D792 S793 C814 C655 D659 S660 C681
Gene Ontology
Molecular Function
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0016746 acyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0042791 5S class rRNA transcription by RNA polymerase III
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cli, PDBe:8cli, PDBj:8cli
PDBsum8cli
PubMed37418517
UniProtQ9UKN8|TF3C4_HUMAN General transcription factor 3C polypeptide 4 (Gene Name=GTF3C4)

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