Structure of PDB 8cgy Chain B

Receptor sequence
>8cgyB (length=447) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
ENTNLRTKTLRDGTTAEELFSQDGLSFNDFIILPGFIDFDSSKVNVSGQF
TKNILLHLPLVSSPMDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVR
SVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLL
GIVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHG
YLPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADK
GRVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQ
DQAKNLIDAGADSLRIGMGLACGRPQATAIYKVARYAASRGVPCVADGGL
RNVGDVCKALAVGANVAMLGSMIAGTSETPGEYFFKDGMRLKGAVLDKGS
VLKLLAYIHKGLQQSAQDIGEVSFDAIREKVYEGQVLFNRRSLTAQS
3D structure
PDB8cgy InCellCryst - A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B C155 T156 K157 D158 T174 M179 T180 H200 Y202 C154 T155 K156 D157 T173 M178 T179 H199 Y201
BS02 GDP B I111 K113 K115 I135 G137 L215 I110 K112 K114 I134 G136 L214
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cgy, PDBe:8cgy, PDBj:8cgy
PDBsum8cgy
PubMed38402242
UniProtP50098|IMDH_TRYBB Inosine-5'-monophosphate dehydrogenase

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