Structure of PDB 8cgw Chain B

Receptor sequence
>8cgwB (length=853) Species: 9606 (Homo sapiens) [Search protein sequence]
KLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNII
LHSTGHNISRVTFMSEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEY
SANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKA
TFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIV
GEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYP
LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIA
HELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLD
ARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYL
SEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQ
KGFPLVTVQKKGKELFIQQERFFLNMTSYLWHIPLSYVTERNYSKYQSVS
LLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYV
LSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQT
DLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA
LLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDK
GWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQ
KLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTY
LFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLT
WWL
3D structure
PDB8cgw Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
ChainB
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H464 H468 E487 H301 H305 E324
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8cgw, PDBe:8cgw, PDBj:8cgw
PDBsum8cgw
PubMed38244767
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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